PROCESS FOR PRODUCTION OF INTERMEDIATE FOR MEROPENEM

摘要

Disclosed is a process for production of p- nitrobenzyl (4R,5S,6S)-3-[[(3S,5S)-1-(p- nitrobenzyloxycarbonyl)-5-(dimethylaminocarbonyl)-3- pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo- 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate, which is useful as an intermediate for the synthesis of meropenem. In the process, the isolation of the carboxylate can be completed within a short time, because the isolation of the carboxylate is achieved by mixing a solution of a rich solvent for the carboxylate with such an amount of a solution of a poor solvent for the carboxylate that the carboxylate is not precipitated as an oily material during the mixing.