CETIRIZINE HYDROCHLORIDE-CONTAINING PARTICLE

摘要

PROBLEM TO BE SOLVED: To provide a cetirizine hydrochloride-containing particle masking the bitterness of the cetirizine hydrochloride having histamine H1 receptor antagonism, used as an anti-allergic agent and having excellent long-term preservability and to provide a cetirizine hydrochloride-containing pharmaceutical preparation. SOLUTION: The cetirizine hydrochloride-containing particle is obtained by thermally melting and granulating a bitterness masking agent which is a combination of acesulfame potassium withβ-cyclodextrin, magnesium aluminometasilicate, a low-melting oily and fatty substance (particularly carnauba wax) and the cetirizine hydrochloride in the absence of a solvent. The cetirizine hydrochloride-containing pharmaceutical preparation comprises the particle. COPYRIGHT: (C)2008,JPO&INPIT