COMPOSITIONS OF LESS IMMUNOGENIC AND LONG-CIRCULATING PROTEIN-LIPID COMPLEXES

摘要

Provided are lipidic particles comprising phopatidylcholine, phosphatidyl inositol and cholesterol. Also provided are compositions comprising the lipi dic particles and having associated therewith therapeutic agents such as pep tides, polypeptides or proteins. In these compositions, the therapeutic agen ts have reduced immunogenicity and/or longer circulating time. These composi tions can be used for therapeutic administration of the peptides, polypeptid es and/or proteins.