发明名称 |
PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS |
摘要 |
Disclosed is a process for producing a compound represented by general formula (II-a): (see formula I) wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (II-a)] or the lactone form of Compound (II-a) [hereinafter referred to as Compound (II-b)] which comprises subjecting a compound represented by general formula (I-a): (see formula II) (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (I-a)] or the lactone form of Compound (I-a) [hereinafter referred to as Compound (I-b)] to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.
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申请公布号 |
CA2299634(C) |
申请公布日期 |
2007.10.16 |
申请号 |
CA19982299634 |
申请日期 |
1998.07.30 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
MOTOYAMA, HIROAKI;OCHIAI, KEIKO;OZAKI, AKIO;ANDO, KATSUHIKO;MORI, HIDEO;TAKANO, YUTAKA;HASEGAWA, MASARU |
分类号 |
C12N1/20;C12P7/62;C12P17/06 |
主分类号 |
C12N1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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