Type III allergic inflammation model animal

摘要

The present invention provides an experimental model animal which does not develop anaphylaxis, a type I allergy, can specifically induce Arthus reaction, a type III allergy, is not affected by type I allergy and evaluates type III allergy inflammation individually, and a method of screening a reaction accelerating or inhibitory substance in a type III allergy reaction through FcgammaRIII by using said experimental model animal. In order to eliminate FcgammaRIIB that demonstrates suppressive action to response through FrgammaRIII, a mouse wherein the deletion mutation of both molecules of Lyn and FcgammaRIIB are homozygotic (Lyn^-IIB^-) was generated by mating Lyn knockout mouse (Lyn^-/-) and FcgammaRIIB knockout mouse (FcgammaRIIB^-/-), and was used to measure and evaluate the deficiency of FcgammaRIII function in systemic passive anaphylaxis and the reduction of FcgammaRIII function in a bone marrow-derived mast cell, or the like.