发明名称 |
Synthetic methodology for the reductive alkylation at the C-3 position of indoles |
摘要 |
A process for the reductive alkylation at the C-3 position of an indole compound in which the indole is treated with an aldehyde in the presence of a Lewis acid and a silicon hydride reducing agent. The process is useful for alkylating the C-3 position of indoles that contain acid-sensitive substituents at the N-1 position.
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申请公布号 |
US7282594(B2) |
申请公布日期 |
2007.10.16 |
申请号 |
US20040014657 |
申请日期 |
2004.12.16 |
申请人 |
WYETH |
发明人 |
MICHALAK RONALD S.;RAVEENDRANATH PANOLIL |
分类号 |
C07D209/04;C07D209/18;C07D209/22;C07D413/02;C07D417/02;C07D493/10 |
主分类号 |
C07D209/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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