发明名称 |
Rhesus HER2/neu, nucleotides encoding same, and uses thereof |
摘要 |
Polynucleotides encoding rhesus monkey HER2/neu have been isolated, cloned and sequenced. The gene encoding the HER2/neu is commonly associated with the development of epithelial-derived human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the HER2/neu tumor-associated antigen, wherein aberrant HER2/neu expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector constructs carrying rhHER2/neu and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
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申请公布号 |
US7282365(B2) |
申请公布日期 |
2007.10.16 |
申请号 |
US20030541270 |
申请日期 |
2003.12.29 |
申请人 |
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. |
发明人 |
MONACI PAOLO;NUZZO MAURIZIO;LA MONICA NICOLA;CILIBERTO GENNARO;LAHM ARMIN |
分类号 |
C07K14/71;A61K38/00;C07K14/485;C12N5/10;C12N15/12 |
主分类号 |
C07K14/71 |
代理机构 |
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地址 |
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