| 摘要 |
The present invention provides a method of crystallization of bicalutamide comprising adding an acetone solution containing bicalutamide to water; crystals of bicalutamide wherein particle size distribution of the crystals is 1 to 10 mum of Dp<SUB>10</SUB>, 10 to 25 mum of Dp<SUB>50 </SUB>and 25 to 100 mum of Dp<SUB>90</SUB>, and the crystals are obtainable by the method described above; and crystals of bicalutamide, wherein particle size distribution of the crystals is 1 to 3 mum of Dp<SUB>10</SUB>, 2 to 5 mum of Dp<SUB>50 </SUB>and 5 to 15 mum of Dp<SUB>90</SUB>.
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