| 摘要 |
<p>Buprenorphine compounds (I) are used to treat emotionally unstable personality disorder, alcohol dependence or multiple substance dependence. Buprenorphine compounds of formula (I) or their salts, esters, ethers, tautomers or hydrates are used to treat emotionally unstable personality disorder, alcohol dependence or multiple substance dependence. X : O, NH, 1-6C alkylimino or S; R 1>-R 4>H, 1-12C alkyl, 2-12C alkenyl, 2-12C alkynyl or (CH 2) nR, all optionally substituted with halo, OH, NO 2, NH 2, mono- or di(1-6C alkyl)amino, guanidino or 1-6C alkoxy and optionally with a CH 2 group replaced by C(O); R : 3-8C (hetero)cycloalkyl, 3-8C (hetero)cycloalkenyl or 6-14C (hetero)aryl; and n : 0-6. An independent claim is also included for a composition comprising (I) and a kappa opioid receptor antagonist. [Image] ACTIVITY : Tranquilizer; Antialcoholic; Antiaddictive. No biological data given. MECHANISM OF ACTION : None given.</p> |
