PIPERIDINE DERIVATIVES USEFUL AS SEROTONIN TRANSPORTER INHIBITORS AND NEUROKININ-1 RECEPTOR ANTAGONISTS

摘要

The present invention relates to trans-derivatives of Formula (I) wherein R<SUP>1</SUP> is hydrogen, halogen or lower alkyl; R<SUP>2</SUP> is hydrogen, lower alkyl or -(CH<SUB>2</SUB>)<SUB>n</SUB>CN; R<SUP>3</SUP> is hydrogen or CF<SUB>3</SUB>; n is 1 or 2; the dotted line may be a bond or not; and to pharmaceutically acceptable acid addition salts thereof. Encompassed by the present formula I are compounds of Formulas (IA) and (IB). The compounds of Formula (I) are good inhibitors of the serotonin transporter (SERT inhibitors) and simultaneously, they have a good activity on the NK-1 receptor (dual effect). By virtue of their efficacy as SERT inhibitors, the compounds in the present invention are particularly useful for the treatment of CNS disorders and psychotic disorders, in particular in the treatment or prevention of depressive states and/or in the treatment of anxiety.