| 摘要 |
Compounds of formula (I) the N-oxides, salts, stereoisomeric forms, prodrugs, esters and metabolites thereof, wherein X is NR<SUP>2</SUP>, O, S, SO, SO<SUB>2</SUB>; R<SUP>1 </SUP>is hydrogen, cyano, halo, a carbonyl derivative, methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C<SUB>1-4</SUB>alkyl)-methanimidamidyl, Het<SUB>1 </SUB>or Het<SUB>2</SUB>; n is 1, 2 or 3; R<SUP>2 </SUP>is (i) aryl substituted with a radical -COOR<SUP>4</SUP>; (ii) C<SUB>1-10</SUB>alkyl, C<SUB>2-10</SUB>alkenyl, C<SUB>3-7</SUB>cycloalkyl, substituted with aryl which is substituted with a radical -COOR<SUP>4</SUP>; (iii) C<SUB>1-10</SUB>alkyl, C<SUB>2-10</SUB>alkenyl, C<SUB>3-7</SUB>cycloalkyl, substituted with -NR<SUP>5a</SUP>-C(-NR<SUP>5b</SUP>)-NR<SUP>5c</SUP>R<SUP>5d</SUP>, -O-NR<SUP>5a</SUP>-C(-NR<SUP>5b</SUP>)-NR<SUP>5c</SUP>R<SUP>5d</SUP>, -sulfonyl-R<SUP>6</SUP>, -NR<SUP>7</SUP>R<SUP>8</SUP>, -NR<SUP>9</SUP>R<SUP>10</SUP>, a radical (a-1), (a-2), (a-3), (a-4), (a-5); or (iv) a radical of formula: (a-6), (b-2), -C<SUB>p</SUB>H<SUB>2p</SUB>-CH(OR<SUP>14</SUP>)-C<SUB>q</SUB>H<SUB>2q</SUB>-R<SUP>15</SUP>; -CH<SUB>2</SUB>-CH<SUB>2</SUB>-(O-CH<SUB>2</SUB>-CH<SUB>2</SUB>)<SUB>m</SUB>-OR<SUP>14</SUP>; -CH<SUB>2</SUB>-CH<SUB>2</SUB>-(O-CH<SUB>2</SUB>-CH2)<SUB>m</SUB>-NR<SUP>17a</SUP>R<SUP>17b</SUP>; R<SUP>3 </SUP>is nitro, cyano, amino, halo, hydroxy, C<SUB>1-4</SUB>alkyloxy, a carbonyl derivative, methanimidamidyl, mono- or di(C<SUB>1-4</SUB>alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het<SUB>1</SUB>.
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