A PROCESS FOR THE PREPARATION OF ARIPIPRAZOLE

摘要

The present invention relates to an improved process for the preparation of 7-[4[-(2, 3-dichlorophenyl)-1-piperazinyl] butoxy] 3, 4-dihydro-2-(1H) quinolinone (Aripiprazole) having dimer impurity less than 0.15%, particularly, the present invention relates to an improved process for the preparation of 7-(4-chlorobutoxy)-3, 4-dihydrocarbostyril of formula (I) having dimer impurity less than 0.5% comprising a step of, reacting 7-hydroxy-tetrahydroquinolinone of formula (III) with 1-bromo-4-chlorobutane in the presence of a base in a solvent.