| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide new isomer and 42-epimer of rapamycin analog having different polarity of whole compounds capable of exerting different stability and solubility characteristics in compositions. <P>SOLUTION: Isomers and 42-epimers of rapamycin alkyl ether analogs and pharmaceutically acceptable salts or prodrugs thereof, are immunomodulatory agents and are useful in the treatment of restenosis and immune and autoimmune diseases. Also disclosed are cancer-, fungal growth-, restenosis-, post-transplant tissue rejection- and immune- and autoimmune disease-inhibiting compositions and a method of inhibiting them. The preferrable application of such isomers and 42-epimers of rapamycin alkyl ether analogs is in medicated devices and local vascular delivery wherein the stability and lipid solubility and subsequently diffusion through tissue and cell membranes are essential to the success of rapamycin containing combination devices. <P>COPYRIGHT: (C)2008,JPO&INPIT |
