COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF

摘要

At least one compound chosen from compounds of Formula 1: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each Of R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB> and R<SUB>5</SUB> is independently chosen from -H, alkyl, substituted aikyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z' is chosen from -O-, -N-, -NO-, - NR<SUB>4</SUB>-, -S-, -SO- and -SO<SUB>2</SUB>-, wherein R<SUB>4</SUB> is defined as above; each of X, X', Y and Z is independently chosen from -CR<SUB>4</SUB>R<SUB>5</SUB>-, -NH-, -NR<SUB>4</SUB>-, -NO-. -O-, -NOR<SUB>4</SUB>-, -S-, -SO-, -SO<SUB>2</SUB>-, wherein R<SUB>4</SUB> and R<SUB>5</SUB> are defined as above; R<SUB>1</SUB> is chosen from a tocopherol, a steroid and a flavonoid; and R<SUB>6</SUB>, is chosen from any R<SUB>1</SUB>, alkyl. substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.