| 摘要 |
A novel, lightweight bioactive wound dressing is provided which offers infection-resistance as well as localized wound healing properties. The wound dressing is comprised of preformed fibrous matter, which is comprised of either a composition which intrinsically provides multiple chemical groups which are functional for subsequent chemical reaction; or is a composition which has been chemically modified at its exterior surface to present a range of chemical groups which are functional for subsequent chemical reaction. These multiple functional chemical groups serve as a plurality of anchorage sites and backbone for the subsequent immobilization of an independently bound biologically active protein. Preferably, a broad-spectrum antibiotic such as the fluoroquinolone, ciprofloxacin, is incorporated into the preformed fibrous matter, using a newly created Pad/Autoclaving technique. Following antibiotic incorporation, the exterior surface of the fibrous matter has a biologically-active protein-such as thrombin, a pivotal enzyme in the blood coagulation cascade-covalently attached and permanently bound to the exterior surface as an aid for enhanced clotting propensity and to help establish hemostasis in-vivo.
|
