| 摘要 |
Disclosed herein are methods, systems, and apparatus for treating a medic al condition of a patient, involving detecting a physiological cycle or cycl es of the patient and applying an electrical signal to a portion of the pati ent's vagus nerve through an electrode at a selected point in the physiologi cal cycle(s). The physiological cycle can be the cardiac and/or respiratory cycle. The selected point can be a point in the cardiac cycle correlated wit h increased afferent conduction on the vagus nerve, such as a point from abo ut 10 msec to about 800 msec after an R-wave of the patient's ECG, optionall y during inspiration by the patient. The selected point can be a point in th e cardiac cycle when said applying increases heart rate variability, such as a point from about 10 msec to about 800 msec after an R-wave of the patient 's ECG, optionally during expiration by the patient. |
