BINDING PARTNERS WITH IMMUNOGLOBULIN DOMAINS MODIFIED TO HAVE EXTENDED HALF-LIFE
摘要
A method for conjugation of glycosylated Fc-containing proteins is described. The method comprises carbamate chemistry performed and neutral pH or below and the resulting Fc-containing protein are expected to retain tertiary structure and therefore Fc-related bioactivity such as FcR binding, the ability to bind C1q, in addition to retaining ligand binding capabilities related to the incorporation of a ligand binding peptide or other polypeptide which has binding specificity. The method is exemplified using an erythropoietin-mimetic peptide fused to a human IgG1 antibody constant domain comprising a hinge, CH2 and CH3.
申请公布号
WO2007115150(A2)
申请公布日期
2007.10.11
申请号
WO2007US65610
申请日期
2007.03.30
申请人
CENTOCOR, INC.;SCALLON, BERNARD;HUTCHINS, MARIA, U.;ZALIPSKY, BERNARD, J.
发明人
SCALLON, BERNARD;HUTCHINS, MARIA, U.;ZALIPSKY, BERNARD, J.