MULTIANALYTE BIOSENSORS BASED ON MONOLITHIC OPTOELECTRONIC TRANSDUCERS

摘要

Monolithic optical biosensors for sensing biomolecules are disclosed. In one aspect, the biosensors comprising a plurality of light-emitting elements and optical waveguides, each waveguide optically coupled to a light-emitting element; and an optical detector, wherein the optical biosensor is adapted to detect an analyte by binding of the analyte on a surface of one or more of the waveguides and thereby changing the optical coupling between the optical detector and one or more of the light emitting elements. In another aspect, a biosensor comprises a light emitting element, an optical waveguide optically coupled to the light emitting element and to an optical detector, the optical waveguide having a plurality of surface features adapted to effect a change in optical coupling between the light emitting element and the optical detector when biomolecules to be sensed are provided over the waveguide.