发明名称 |
Process for obtaining growth factor (TGF-BETA and IGF-1), lactoperoxidase and immunoglobulins preparations from milk products having low mutual cross-contamination |
摘要 |
The present invention relates to a process for extracting beneficial compounds, in particular growth factors, such as TGF beta and IGF-1 from milk. In this process a hydrophobic interaction chromatography step is included. A resin having a butyl group, or a phenyl group as the ligand is used as hydrophobic interaction resin. The resin can be eluted with a salt gradient which, when the ligand is a phenyl group, contains substantially no alcohol, and thus resulting in fractions enriched in the desired growth factors. These fractions can be separated further by means of a hydroxyapatite column. |
申请公布号 |
AU2002318066(B2) |
申请公布日期 |
2007.10.11 |
申请号 |
AU20020318066 |
申请日期 |
2002.07.22 |
申请人 |
CAMPINA B.V.;NUMICO RESEARCH B.V. |
发明人 |
MARINUS GERARDUS CORNELIS KIVITS;CATHARINA MARIA GALAMA;ANDOR WILHELM JOSEPH HENDRIKS |
分类号 |
C07K14/495;A23J1/20;A23L11/00;C07K14/65;C07K16/04;C12N9/08 |
主分类号 |
C07K14/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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