Monoclonal antibody specific for beta A4 peptide

摘要

The instant invention provides for monoclonal antibody which is specific for the ²A4 peptide, and in particular the free C-terminus of ²A4 "1-42" but not "1-43", and stains diffuse and fibrillar amyloid, vascular amyloid and neurofibrillary tangles. The instant invention further provides for antibody fragments and constructs thereof which have the same binding specificity. The instant invention also provides for methods of diagnosis, screening and therapeutics for treating unique forms of ²A4 peptide, using the antibodies of the instant invention.