发明名称 |
COMPARTMENTALISED SCREENING BY MICROFLUIDIC CONTROL |
摘要 |
The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development. |
申请公布号 |
EP1842067(A2) |
申请公布日期 |
2007.10.10 |
申请号 |
EP20050792856 |
申请日期 |
2005.10.12 |
申请人 |
MEDICAL RESEARCH COUNCIL;PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
GRIFFITHS, ANDREW;WEITZ, DAVID;LINK, DARREN;AHN, KEUNHO;BIBETTE, JEROME |
分类号 |
G01N33/543;B01F3/08;B01F5/02;B01F5/06;B01F13/00;B01J19/00;B01L3/00;C12Q1/68;C40B50/08;G01N15/14;G01N33/53;G01N33/555 |
主分类号 |
G01N33/543 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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