ВАКЦИННАЯ КОМПОЗИЦИЯ ДЛЯ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ОНКОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ, ГЕНЕТИЧЕСКИЕ КОНСТРУКЦИИ И СПОСОБ ПОЛУЧЕНИЯ КОМПОНЕНТОВ ЭТОЙ КОМПОЗИЦИИ

摘要

FIELD: biotechnology, gene engineering, medicine. ^ SUBSTANCE: claimed composition contains inert carrier, diluent, and antigen component in effective amount. As antigen component it contains hybrid proteins such as PEPHER2/neu.1-HSP70, PEPHER2/neu.2-HSP70, PEPHER2/neu.3-HSP70 or PERErbB1vIII-HSP70, or mixture thereof. Also disclosed are recombinant plasmid DNA encoding biosynthesis of hybrid proteins comprising in vaccine composition and method for production thereof by their gene expression in composition of recombinant proteins in E.coli followed by purification of target product. ^ EFFECT: new anti-tumor preparation. ^ 6 cl, 1 dwg, 9 ex