摘要 |
<p>The N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 1, 2, 3, or 4; Z represents O, S, NR<sup>6</sup>, SO or SO<sub>2</sub>; R<sup>1</sup> represent hydrogen, cyano, hydroxy, or C<sub>1-4</sub>alkyl optionally substituted with halo, R<sup>2</sup> represents hydrogen, C<sub>1-4</sub>alkyl, or C<sub>1-4</sub>alkyloxy-; R<sup>3</sup> represents hydrogen, C<sub>1-4</sub>alkyl, C<sub>1-4</sub>alkyloxy- or R<sup>3</sup> combined with R<sup>2</sup> form together a divalent radical selected from the group consisting of -O-CH<sub>2</sub>- (a), -NR<sup>7</sup>-CH<sub>2</sub>- (b), -(CR<sup>8</sup>R<sup>9</sup>)<sub>m</sub>- (c) and -CR<sup>10</sup>= (d) wherein m represents 1 or 2 and R<sup>7</sup>, R<sup>8</sup>, R<sup>9</sup> and R<sup>10</sup> are each independently selected from hydrogen or C<sub>1-4</sub>alkyl; R<sup>4</sup> represents hydrogen, halo, hydroxy, cyano, amino, NR<sup>11</sup>R<sup>12</sup>, C<sub>1-4</sub>alkyloxy- optionally substituted with one or where possible two or three substituents selected from hydroxy and halo or R<sup>4</sup> represents C<sub>1-4</sub>alkyl optionally substituted with one or where possible two or three substituents selected from hydroxy and halo; R<sup>5</sup> represents hydrogen, halo, cyano, amino, phenyl, hydroxy, C<sub>1-4</sub>alkyloxycarbonyl, hydroxycarbonyl, NR<sup>13</sup>R<sup>14</sup> or C<sub>1-4</sub>alkyl substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C<sub>1-4</sub>alkyloxy or NR<sup>15</sup>R<sup>16</sup>; R<sup>6</sup> represents hydrogen; R<sup>11</sup> and R<sup>12</sup> each independently represent hydrogen, C<sub>1-4 </sub>alkyl or C<sub>1-4 </sub>alkylcarbonyl-; R<sup>13</sup> and R<sup>14</sup> each independently represent hydrogen, C<sub>1-4</sub>alkyl or C<sub>1-4 </sub>alkylcarbonyl-; R<sup>15</sup> and R<sup>16</sup> each independently represent hydrogen, C<sub>1-4 </sub>alkyl or C<sub>1-4 </sub>alkylcarbonyl-; R<sup>17</sup> and R<sup>18</sup> each independently represent hydrogen, C<sub>1-4</sub>alkyl or C<sub>1-4 </sub>alkylcarbonyl-.</p> |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
WILLEMSENS, GUSTAAF HENRI MARIA;JAROSKOVA, LIBUSE;LINDERS, JOHANNES THEODORUS MARIA;VAN DER VEKEN, LOUIS JOSEF ELISABETH;BISCHOFF, FRANCOIS PAUL |