| 摘要 |
A process for preparing alkyl 2-[3-[3-[(2E)-(7-chloro-quinolin-2-yl)vinyl]phenyl]-3(S)-hydroxypropyl]benzoate is provided to improve economical efficiency by using inexpensive reagents, and enhance preparation yield by performing reaction under mild condition. A process for preparing alkyl 2-[3-[3-[(2E)-(7-chloro-quinolin-2-yl)vinyl]phenyl]-3(S)-hydroxypropyl]benzoate represented by the formula(1) comprises the steps of: (i) oxidizing isochromene represented by the formula(2) to prepare 1-isochromenone represented by the formula(3); (ii) ring-opening reacting the 1-isochromenone represented by the formula(3) under bromic acid and iodide catalyst, and reacting the resulting product with alcohol compound represented by R-OH to prepare benzoic acid ester derivatives represented by the formula(4); and (iii) Grignard-reacting the benzoic acid ester derivatives represented by the formula(4) with benzoaldehyde derivatives represented by the formula(5), wherein R is C1-C15 alkyl group, phenyl group or benzyl group.
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