发明名称 |
Process for the preparation of high purity perindopril |
摘要 |
The invention relates to 1-{2(S)-[1(S)-(ethoxycarbonyl)butylamino]propionyl}-(3aS,7aS)octahydroindol-2(S)-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I' thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a process for the preparation thereof. The invention also relates to new intermediates of the general Formula III (wherein R stands for lower alkyl or aryl lower alkyl). The compound of the Formula I-perindopril-is a known ACE inhibitor.
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申请公布号 |
US7279595(B2) |
申请公布日期 |
2007.10.09 |
申请号 |
US20070788454 |
申请日期 |
2007.04.20 |
申请人 |
LES LABORATOIRES SERVIER |
发明人 |
SIMIG GYULA;MEZEI TIBOR;PORCS-MAKKAY MARTA;MANDI ATTILA |
分类号 |
A61K31/404;C07C61/00;A61P9/12;A61P43/00;C07C229/00;C07D209/42 |
主分类号 |
A61K31/404 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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