发明名称 |
DRUG DELIVERY COMPOSITION CONTAINING CHITOSAN OR DERIVATIVE THEREOF HAVING A DEFINED Z. POTENTIAL |
摘要 |
A drug delivery composition for administration to mucosa is provided. The composition comprises a pharmacologically active compound and particles, preferably powder or microspheres, of chitosan or a chitosan derivative or salt wherein the particles are either solidified or partially cross-linked such that they have a zeta-potential of +0.5 to +50 mV. Solidified particles are made by treating particles made from a water soluble chitosan salt with an alkaline agent such as sodiu m hydroxide in non-acid containing water to render them insoluble.
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申请公布号 |
CA2197062(C) |
申请公布日期 |
2007.10.09 |
申请号 |
CA19952197062 |
申请日期 |
1995.08.21 |
申请人 |
DANBIOSYST UK LIMITED |
发明人 |
WATTS, PETER JAMES;ILLUM, LISBETH |
分类号 |
A61K38/28;A61K9/00;A61K9/16;A61K31/485;A61K38/23;A61K47/36 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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