发明名称 |
Crystal of glucokinase protein, and method for drug design using the crystal |
摘要 |
Glucokinase is crystallized, the three-dimensional structure thereof is analyzed, and then a compound to be bonded to glucokinase is designed on the basis of the coordinate for the resulting three-dimensional structure. Specifically, glucokinase is freed of a part of amino acid residues being on the N-terminal side thereof, to thereby crystallize it, and the three-dimensional structure of the resulting crystal is elucidated through the X-ray crystallographic analysis thereof.
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申请公布号 |
US2007231874(A1) |
申请公布日期 |
2007.10.04 |
申请号 |
US20030514928 |
申请日期 |
2003.05.15 |
申请人 |
KAMATA KENJI;NAGATA YASUFUMI;IWAMA TOSHIHARU |
发明人 |
KAMATA KENJI;NAGATA YASUFUMI;IWAMA TOSHIHARU |
分类号 |
C12N9/12;G01N33/48;G01N33/50;G06F19/00 |
主分类号 |
C12N9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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