摘要 |
What is described is a pharmaceutical formulation for intranasal administration of exendin to a mammal, wherein the formulation comprises a therapeutically effective amount of an exendin, a viscosity enhancer, methyl-ß-cyclodextrin, a surfactant, tartrate buffer to control pH and a chelating agent for cations, and wherein such exendin dosage form exhibits at least 95% exenatide recovery after storage for at least 365 days at 5°C. |
申请人 |
NASTECH PHARMACEUTICAL COMPANY INC.;QUAY, STEVEN, C.;COSTANTINO, HENRY, R.;LEONARD, ALEXIS, KAYS |
发明人 |
QUAY, STEVEN, C.;COSTANTINO, HENRY, R.;LEONARD, ALEXIS, KAYS |