METHOD FOR PREPARING SUSTAINED-RELEASE MICROPARTICLES COMPRISING SUCROSE ACETATE ISOBUTYRATE
摘要
A sustained release microparticles which is capable of releasing a protein drug continuously over a long period of time without initial burst release of the drug can be simply prepared by a method comprising the steps of a) dissolving a protein drug in an aqueous solution to obtain a water phase; b) dissolving sucrose acetate isobutyrate(SAIB) and a biodegradable polymer in an organic solvent to obtain an oil phase; c) adding the water phase obtained in step a) to the oil phase obtained in step b) to form a primary emulsion; and d) adding the primary emulsion to an external aqueous continuous phase to form a secondary emulsion and recovering the solid product formed in the secondary emulsion.
申请公布号
WO2007058462(A9)
申请公布日期
2007.10.04
申请号
WO2006KR04799
申请日期
2006.11.15
申请人
AMOREPACIFIC CORPORATION;LEE, EUN SEONG;LEE, HYEOK;KIM, JUNG JU