| 摘要 |
<p>Compounds of the general formula (1), salts thereof and their hydrates. (1) In the formula, each of R<SUP>1a</SUP>, R<SUP>1b</SUP>, R<SUP>1c</SUP> and R<SUP>1d</SUP> independently is a hydrogen atom, etc. R<SUP>2</SUP> is an optionally substituted phenyl, etc. R<SUP>3</SUP> is an optionally substituted C<SUB>6-10</SUB> aryl, etc. Each of Z<SUP>1</SUP> and Z<SUP>2</SUP> independently is a hydrogen atom. They are useful as a therapeutic agent and/or preventive for diseases caused by clot formation, being safer, and have appropriate physicochemical stability.</p> |
| 申请人 |
EISAI R & D MANAGEMENT CO., LTD.;CLARK, RICHARD;MATSUURA, FUMIYOSHI;KIRA, KAZUNOBU;HIROTA, SHINSUKE;AZUMA, HIROSHI;NAGAKURA, TADASHI;HORIZOE, TATSUO;TABATA, KIMIYO;KUSANO, KAZUTOMI;OMAE, TAKAO;INOUE, ATSUSHI |
发明人 |
CLARK, RICHARD;MATSUURA, FUMIYOSHI;KIRA, KAZUNOBU;HIROTA, SHINSUKE;AZUMA, HIROSHI;NAGAKURA, TADASHI;HORIZOE, TATSUO;TABATA, KIMIYO;KUSANO, KAZUTOMI;OMAE, TAKAO;INOUE, ATSUSHI |
