PREVENTION OF NEURODEGENERATION BY MACROLIDE ANTIBIOTICS
摘要
The present disclosure describes the use of macrolide antibiotics to prevent neurodegeneration and to treat or prevent disease and conditions which involve neurodegeneration. While not being limited to a specific mechanism of action, in one embodiment, the macrolide antibiotics inhibit neurodegeneration caused by lysosomal and/or mitochondrial dysfunction. The present disclosure contemplates the use of any macrolide antibiotic and pharmaceutically acceptable derivatives thereof. In a specific embodiment, the macrolide antibiotics include bafilomycin A1, bafilomycin B1 and concanamycin.
申请公布号
WO2007022076(A3)
申请公布日期
2007.10.04
申请号
WO2006US31619
申请日期
2006.08.14
申请人
THE UAB RESEARCH FOUNDATION;SHACKA, JOHN, J.;ROTH, KEVIN, A.