发明名称 |
Active substance fraction from Rheum species, obtained by extracting Rheum root samples with methanol, separating lipophilic material and condensing the fraction, useful to treat and prevent e.g. inflammatory diseases |
摘要 |
<p>Active substance fraction from Rheum species, to treat and prevent e.g. inflammatory diseases, where the preparation of active substance fraction comprises: extracting dried and ground root samples with methanol; separating lipophilic material from the formed aqueous phase; agitating the purified aqueous phase with ethylacetate; column chromatographically separating the resulting aqueous phase and the combined ethylacetate phase to a limited number of active substance fractions; and condensing the active substance fraction with same content spectrum. Active substance fraction from Rheum species for treating and preventing inflammatory or autoimmune disorder and/or diseases associated with keratinocyte proliferation disturbances, where the preparation of active substance fraction comprises: extracting dried and ground root samples with methanol; separating lipophilic material from the formed aqueous phase under complete removal of methanol; agitating the purified aqueous phase with ethylacetate; separately processing the resulting aqueous phase and the combined ethylacetate phase; column chromatographically separating the resulting aqueous phase and the combined ethylacetate phase to a limited number of active substance fractions; and condensing the active substance fraction with same content spectrum. ACTIVITY : Antiinflammatory; Immunosuppressive; Antiarthritic; Antirheumatic; Gastrointestinal-Gen; Antiulcer; Antipsoriatic; Dermatological; Antimicrobial; Vulnerary. MECHANISM OF ACTION : Interleukin (IL)-1beta and/or IL-2-mRNA-expression inducer; Transforming growth factor (TGF)-beta 1 inducer; IL-1beta or IL-2 suppressor. The ability of the active substance fraction to modulate IL-2-mRNA expression of human phytohaemagglutinin stimulated mononuclear cell. The result showed that the active substance fraction significantly induced the IL-2-mRNA-expression.</p> |
申请公布号 |
DE102006015574(A1) |
申请公布日期 |
2007.10.04 |
申请号 |
DE20061015574 |
申请日期 |
2006.04.03 |
申请人 |
ESA PATENTVERWERTUNGSAGENTUR SACHSEN-ANHALT GMBH;HOCHSCHULE ANHALT (FH) |
发明人 |
KABRODT, KATHRIN;SCHELLENBERG, INGO;LENDECKEL, UWE;WOLKE, CARMEN |
分类号 |
A61K36/708;A61P37/00 |
主分类号 |
A61K36/708 |
代理机构 |
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代理人 |
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主权项 |
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