发明名称 MACROCYCLE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
摘要 The present invention is directed to macrocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors ofß-secretase, also known as ß-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
申请公布号 WO2007092839(A3) 申请公布日期 2007.10.04
申请号 WO2007US61677 申请日期 2007.02.06
申请人 JANSSEN PHARMACEUTICA N.V.;BAXTER, ELLEN;REITZ, ALLEN B.;PARKER, MICHAEL H.;HUANG, YIFANG;HO, CHIH Y.;STROBEL, ERIC D.;REYNOLDS, CHARLES H. 发明人 BAXTER, ELLEN;REITZ, ALLEN B.;PARKER, MICHAEL H.;HUANG, YIFANG;HO, CHIH Y.;STROBEL, ERIC D.;REYNOLDS, CHARLES H.
分类号 C07D487/08;A61K31/4748;A61K31/529;A61P25/28;C07D498/08;C07D498/18 主分类号 C07D487/08
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