IL-15RALPHA SUSHI DOMAIN AS A SELECTIVE AND POTENT ENHANCER OF IL-15 ACTION THROUGH IL-15RBETA/GAMMA, AND HYPERAGONIST (ILRALPHA SUSHI-IL 15) FUSION PROTEINS

摘要

The present invention relates to the stimulation of the IL-15Rbeta/gamma signalling pathway, to thereby induce and/or stimulate the activation and/or proliferation of IL-15Rbeta/gamma-positive cells, such as NK and/or T cells. Appropriate compounds include compounds comprising at least one IL- 15Rbeta/gamma binding entity, directly or indirectly linked by covalence to at least one polypeptide which contains the sushi domain of the extracellular region of an IL-15Ralpha.