| 摘要 |
A method of providing a cooling sensation to the skin or the mucous membranes of the body by applying thereto a compound of Formula (I) in which X is H or (CH<sub>2</sub>)<sub>n</sub>-R, n is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, phenyl, C1-C4 straight or branched alkyl, or, a C<sub>1</sub>-C<sub>4</sub> straight or branched alkoxy, or X and Y form together a bivalent radical selected from the group consisting of -O-CH<sub>2</sub>-O-, -N=CH-O- and -N=CH-S- which forms together with the carbon atoms to which they are attached a 5-membered ring; and R is a group with non-bonding electrons, R<sup>1</sup> is H or C<sub>1</sub>-C<sub>5</sub> branched alkyl, R2 and R3 are C<sub>1</sub>-C4 branched alkyls, or R<sup>2</sup> and R<sup>3</sup> taken together form a monocyclic, bicyclic or tricyclic radical of up to 10 carbons provided that R<sup>1</sup>, R<sup>2</sup> and R<sup>3</sup> together comprise at least 6 carbons. The compounds may be incorporated into products such as dentifrices, foodstuffs, confectionery, beverages, and cosmetic and medicinal preparations. |
