发明名称 |
THERAPEUTIC PEPTIDE FORMULATIONS FOR COATING MICRONEEDLES WITH IMPROVED STABILITY CONTAINING AT LEAST ONE COUNTERION |
摘要 |
<p>Compositions of and methods for formulating and delivering peptide, polypeptide and protein therapeutic agent formulations having enhanced physical stability, and wherein fibril formation is minimized and/or controlled, to yield a consistent and predictable composition viscosity. The compositions of and methods for formulating and delivering peptide, polypeptide and protein therapeutic agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the peptide therapeutic agents.</p> |
申请公布号 |
EP1838290(A2) |
申请公布日期 |
2007.10.03 |
申请号 |
EP20060719212 |
申请日期 |
2006.01.19 |
申请人 |
ALZA CORPORATION |
发明人 |
CORMIER, MICHEL, J., N.;AMERI, MAHMOUD |
分类号 |
A61K9/30;A61K38/00;A61K38/25;A61K47/02;A61K47/12 |
主分类号 |
A61K9/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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