发明名称 |
INTERMEDIATE FOR THE SYNTHESIS OF AMLODIPINE, A PROCESS FOR THE PREPARATION THEREOF AND CORRESPONDING USE |
摘要 |
An intermediate for the synthesis of amlodipine, a process for the preparation thereof and the corresponding use are disclosed. The intermediate is ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate and is of formula III (See formula III) The process for the preparation thereof comprises reacting the acetoacetate of formula (See formula IV) with ammonium acetate, and the use thereof is for the preparation of the compound of formula (See formula V) the process being conducted by reacting ethyl 3-amino-4-[2- (phthalimido)ethoxy]crotonate with a benzylidene derivative
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申请公布号 |
CA2349013(C) |
申请公布日期 |
2007.10.02 |
申请号 |
CA19992349013 |
申请日期 |
1999.10.18 |
申请人 |
ESTEVE QUIMICA S.A. |
发明人 |
CAMPON PARDO, JULIO;GASANZ GUILLEN, YOLANDA;COPPI, LAURA |
分类号 |
C07D209/48;A61K31/4427;A61K31/444;A61P9/10;C07D211/90;C07D401/12 |
主分类号 |
C07D209/48 |
代理机构 |
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主权项 |
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地址 |
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