| 摘要 |
THIS INVENTION PROVIDES NOVEL PEPTIDES THAT FUNCTION IN VIVO TO STIMULATE INSULIN RELEASE FROM PANCREATIC BETA CELLS IN A GLUCOSE-DEPENDENT FASHION . THESE INSULIN SECRETAGOGUE PEPTIDES OF THE PRESENT INVENTION PROVIDE A NEW THEREPHY FOR PATIENTS WITH DECREASED ENDOGENOUS INSULIN SECRETION , IN PARTICULAR TYPE 2 DIABETICS. IN PARTICULAR , THE INVENTION IS A POLYPEPTIDE SELECTED FROM A SPECIFIC GROUP OF VIP/PACAP-RELATED POLYPEPTIDES, OR FUNCTIONAL EQUIVALENTS THEREOF . THE INVENTION IS ALSO DIRECTED TO A METHOD OF TREATING A METABOLIC DISEASE IN A MAMMAL COMPRISING ADMINISTERING A THEREPEUTICALLY EFFECTIVE AMOUNT OF THE INSULIN SECRETAGOGUE TO SAID MAMMAL . ALSO DISCLOSED ARE METHODS OF MAKING THE PEPTIDES , BOTH RECOMBINANT AND SYNTHETIC .
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