摘要 |
<p>The main subject of the present invention is the use of complexes of NADP with the protein MabA, or with a derived protein, and more particularly the crystallographic coordinates of these proteins in the frame of said complexes, within the framework of the implementation of methods for designing and screening ligands of these proteins, and advantageously ligands inhibiting the enzymatic activity of these proteins, namely antibiotics capable of being used within the framework of the treatment of mycobacteriosis.</p> |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;LABESSE, GILLES;QUEMARD, ANNAIK;COHEN-GONSAUD, MARTIN;DUCASSE-CABANOT, STEPHANIE;DAFFE, MAMADOU |
发明人 |
LABESSE, GILLES;QUEMARD, ANNAIK;COHEN-GONSAUD, MARTIN;DUCASSE-CABANOT, STEPHANIE;DAFFE, MAMADOU |