摘要 |
The invention provides the diastereoselective alkylation of optically active nopinone to form the compound of formula (I) according to scheme A below: in which: R is a C<SUB>5-15 </SUB>alkyl group; R1 is especially a C<SUB>1-15 </SUB>alkyl, C<SUB>2-15 </SUB>alkenyl or C<SUB>2-15 </SUB>alkynyl group or a C<SUB>5-15 </SUB>aryl, each group optionally being substituted; and X is a halogen atom; and the configuration of the compound of formula (I) is either (E) or (Z) or a mixture of the two. The compound of formula (I) is a valuable synthetic intermediate.
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