发明名称 |
HETEROARYL SUBSTITUTED 2-PYRIDINYL AND 2-PYRIMIDINYL -6,7,8,9-TETRAHYDROPYRIMIDO[1,2-a] PYRIMIDIN-4-ONE DERIVATIVES |
摘要 |
The invention relates to use of a pyrimidone derivative represented by formula (I) or a salt thereof wherein: X, Y, R1, R2, R3, R4, R5, m, n and p are as defined herein. In particular, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3beta or GSK3beta and cdk5/p25, such as Alzheimer disease.
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申请公布号 |
US2007225300(A1) |
申请公布日期 |
2007.09.27 |
申请号 |
US20070749349 |
申请日期 |
2007.05.16 |
申请人 |
MITSUBISHI PHARMA CORPORATION |
发明人 |
LOCHEAD ALISTAIR;NEDELEC ALAIN;SAADY MOURAD;YAICHE PHILIPPE |
分类号 |
A61K31/519;A61P3/04;A61P3/10;A61P9/10;A61P17/14;A61P21/00;A61P25/00;A61P25/02;A61P25/08;A61P25/16;A61P25/18;A61P25/24;A61P25/28;A61P25/34;A61P27/02;A61P27/06;A61P35/00;A61P43/00;C07D487/04;C07D519/00 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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