发明名称 |
Three-dimensional structure of complement receptor type 2 and uses thereof |
摘要 |
Disclosed is a crystalline human CR2 protein in complex with C3d, and the three dimensional structure of the crystalline complex. Also disclosed are methods of use of the structure, particularly for structure-based identification of compounds that bind to CR2 and inhibit or enhance the binding of CR2 to a natural ligand, that bind to CR2 and agonize or antagonize the receptor, that bind to CR2 and inhibit or enhance CR2 dimerization, or that use the C3-binding ability of CR2 as a drug delivery vehicle. Also disclosed are therapeutic compounds obtained by such methods and uses for such compounds.
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申请公布号 |
US2007224197(A1) |
申请公布日期 |
2007.09.27 |
申请号 |
US20070786788 |
申请日期 |
2007.04.12 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF COLORADO |
发明人 |
CHEN XIAOJIANG;HOLERS VERNON M. |
分类号 |
A61K39/395;A61K31/00;C07K14/705;C07K16/24;C07K16/28;G06F19/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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