| 摘要 |
FIELD: biotechnology. ^ SUBSTANCE: invention relates to polypeptide conjugate with G-CSF activity including polypeptide with amino acid sequence which is differ from human hG-CSF sequence by 15 amino acid residues and is conjugated with 2-6 polyethylene glycol residues. Said conjugates have low in vitro biological activity, prolonged half-life in vivo, decreased receptor-mediated clearance. ^ EFFECT: accelerated stimulation of leukocyte and neutrophyl formation in contrast to non-conjugated recombinant human G-CSF. ^ 16 cl, 11 dwg, 4 tbl, 21 ex |
