LIPOSOMES ENCLOSING A RADIONUCLIDE AND A CYTOTOXIC AGENT FOR COMBINATION THERAPY

摘要

The present invention relates to cytotoxic agents comprising liposomes wherein the liposomes enclose a solution comprising at least one alpha emitting radionuclide and at least one other therapeutic agent, particularly a chemotherapeutic. The invention also provides methods for the formation of such cytotoxic agents, methods of therapy, especially cancer therapy employing the agents and methods for their use in the manufacture of medicaments.