It is described a stable recombinant stem cell able to express an apophotoprotein and produce a bioluminescent signal in the presence of a suitable chromophore as substrate in response to intracellular calcium concentration variation; methods for identifying agents modulating the differentiation of stem cells towards a specific cell lineage; methods for identifying a ligand able to stimulate a specific cell lineage target; methods for identifying an antagonist to ligand known to stimulate a specific cell lineage target; uses of stable recombinant stem cells for in vitro testing of toxicity and/ teratology of a substance.
申请公布号
WO2007080622(A3)
申请公布日期
2007.09.27
申请号
WO2007IT00021
申请日期
2007.01.10
申请人
AXXAM S.P.A.;CAINARCA, SILVIA;NUCCI, CINZIA;CORAZZA, SABRINA;LOHMER, STEFAN
发明人
CAINARCA, SILVIA;NUCCI, CINZIA;CORAZZA, SABRINA;LOHMER, STEFAN