摘要 |
The present invention relates to an arylalkylamine compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, a process for preparing the same, and use of the above-mentioned compound as an activating compound (CaSR agonist) of a Ca sensing receptor, a pharmaceutical composition containing the above-mentioned compound as an effective ingredient, etc. The symbols in the formula represent the following meanings: Ar: optionally substituted aryl or optionally substituted heteroaryl here, the cyclic portion of the heteroaryl is bicyclic heterocyclic ring in which 5- to 6-membered monocyclic heterocyclic ring containing 1 or 2 hetero atom(s) and benzene ring are fused; R<SUP>1</SUP>: a group selected from the group consisting of optionally substituted cyclic hydrocarbon group, and optionally substituted heterocyclic group; n: an integer of 1 to 3; X: single bonding arm, -CH<SUB>2</SUB>-, -CO-, -(CH<SUB>2</SUB>)<SUB>m</SUB>-CO-, -CH(R<SUP>2</SUP>)-CO-, -(CH<SUB>2</SUB>)<SUB>p</SUB>-Y-(C(R<SUP>3</SUP>)(R<SUP>4</SUP>))<SUB>q</SUB>-CO-, -NH-CO- or -N(R<SUP>5</SUP>)-CO-; in the above-mentioned respective definitions of the X, the bonding arm described at the left end represents a bond with R<SUP>1</SUP>; m is an integer of 1 to 3; p is an integer of 0 to 2; q is an integer of 0 to 2; Y: -O- or -SO<SUB>2</SUB>-; R<SUP>2</SUP>: phenyl or lower alkyl; R<SUP>3</SUP>, R<SUP>4</SUP>: each independently represents hydrogen atom or lower alkyl; R<SUP>5</SUP>: lower alkyl; provided that the ring portion of the group represented by R<SUP>1 </SUP>is neither naphthylidine nor partially saturated group thereof, and, when X is -CH<SUB>2</SUB>- or -CO-, R<SUP>1 </SUP>is not naphthyl.
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