MODULATION OF INNATE IMMUNITY RECEPTORS' SIGNALING BY MICRORNAS MIR-146A AND MIR-146B
摘要
The present disclosure relates to the finding that microRNA-146 plays a role modulating the innate immune response. Innate immunity receptor signaling can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells. In some embodiments, IL-1 receptor associated kinase 1 (IRAK1) and TNF receptor associated factor 6 (TRAF6) expression levels are downregulated in a target cell by administering a miR-146 oligonucleotide. Modulation of the innate immune system through miR-146 can be used to treat a variety of diseases and disorders associated with activation of the innate immune system, such as sepsis and Crohn's disease.
申请公布号
WO2007109350(A2)
申请公布日期
2007.09.27
申请号
WO2007US07091
申请日期
2007.03.22
申请人
CALIFORNIA INSTITUTE OF TECHNOLOGY;BALTIMORE, DAVID;BOLDIN, MARK;TAGANOV, KONSTANTIN