ANTI-INFLAMMATORY PHOSPHONATE COMPOUND

摘要

PROBLEM TO BE SOLVED: To provide a new anti-inflammation agent such as a drug having improved anti-inflammatory property, improved pharmacological property, improved activity, improved bioavailability and improved effective half-life period in vivo. SOLUTION: The invention provides a conjugated material containing an anti-inflammatory compound linked to one or more phosphonate groups and its pharmacologically allowable salt or solvate. In one embodiment, the compound of the conjugated material is either one compound substituted with one or more A0groups and expressed by formulas 500-611. COPYRIGHT: (C)2007,JPO&INPIT