发明名称 |
Polymeric chelators for radionuclide delivery systems |
摘要 |
A radionuclide delivery system that is based upon amorphous, water-soluble polymeric chelators. Each water-soluble polymeric chelator is capable of delivering hundreds of radionuclide atoms to the target. The chemical and physical characteristics of the globular polymer increase the effective decay-particle yield at the target cells and reduce ancillary toxicity due to errant daughter radionuclides by retaining or rebinding daughter nuclei. The delivery system includes a water-soluble polymeric chelator having a plurality of chelating groups; and a plurality of radionuclide atoms bound to a least a portion of the chelating groups, wherein the plurality of chelating groups immobilize at least a portion of the plurality of radionuclide atoms.
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申请公布号 |
US2007224115(A1) |
申请公布日期 |
2007.09.27 |
申请号 |
US20060388177 |
申请日期 |
2006.03.22 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
BARR MARY E.;ATCHER ROBERT W. |
分类号 |
A61K51/00 |
主分类号 |
A61K51/00 |
代理机构 |
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地址 |
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