发明名称 |
Substituted dibenzo-azepine and benzo-diazepine derivatives useful as gamma-secretase inhibitors |
摘要 |
The present invention provides compounds of the general formula wherein R<SUP>4 </SUP>is one of the following groups and R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>7</SUP>, R<SUP>8</SUP>, and R<SUP>9 </SUP>are as defined in the specification and pharmaceutically acceptable salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. The compounds are useful for the treatment of Alzheimer's disease. |
申请公布号 |
ZA200602802(B) |
申请公布日期 |
2007.09.26 |
申请号 |
ZA20060002802 |
申请日期 |
2006.04.05 |
申请人 |
F. HOFFMANN-LA ROCHE AG. |
发明人 |
FLOHR, ALEXANDER;JAKOB-ROETNE, ROLAND;PETERS, JENS-UWE;GALLEY, GUIDO;KITAS, ERIC ARGIRIOS;WOSTL, WOLFGANG |
分类号 |
A61K;A61P;C07D;C07D223/16;C07D223/18;C07D243/12;C07D243/24;C07D409/12 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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